UCSD Department of Chemistry
and Biochemistry

Supported By

The facility is supported by the National Institute for Environmental Health and Sciences SUPERFUND Grant and the NIH Research Resources Program.

Welcome to the Biomolecular and Proteomics Mass Spectrometry Facility

The overall goals of the Biomolecular/Proteomics Mass Spectrometry Facility are to collaborate with university of California San Diego (UCSD) researchers and to collect the highest quality mass spectrometry data possible on biological samples. The facility is actively engaged in developing proteomic technologies and also provides access to more routine instrumentation for protein and peptide mass spec analyses.

Facility Personnel

Facility Director Majid Ghassemian Has been conducting research in the field of genomic/proteomics sciences for the past 12 years.

Faculty Oversight Elizabeth Komives Is focused on understanding the parameters that govern protein-protein interactions mediated by non-globular proteins.

New protein quantification Service:

Proteome scale quantitation analysis using iTRAQ and High pH Reverse Phase (HPRP) for first dimension separation analysis.

Click to see our Poster at the 10th International Symposium on Mass Spectrometry in the Health & Life Sciences.

New MS Instrument:

ABSCIEX TripleTOF 5600. The AB SCIEX TripleTOF™ 5600 System is an innovative breakthrough in LC-MS2 performance that uniquely integrates comprehensive qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform. It combines the highest sensitivity detection, high-resolution with better acquisition speed, and stable ~1ppm mass accuracy over days of acquisition.

Courses:

CHM283\BENG283\BIOM208
A graduate course, with both laboratory and lecture series, to train students in the theories and practical applications of protein mass spectrometry. Course is offered in the spring of 2012.

Recent Publications

Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal.

Sequential interactions with Sec23 control the direction of vesicle traffic. Nature.

Automated querying and identification of novel peptides using MALDI mass spectrometric imaging. J. of Proteomics Res.